Fluid drying mechanism

ABSTRACT

There is provided an exhaled breath moisture reduction system including a dryer mechanism and a connector adapted to connect the dryer mechanism proximate to a respiratory output device. There is also provided an exhaled breath sampling assembly including an airway adaptor and a moisture reduction sleeve comprising a material adapted to reduce moisture and a connector adapted to connect said sleeve substantially adjacent to a breath sampling inlet within the adaptor. Also provided, a method of sampling breath which includes attaching an exhaled breath moisture reduction sleeve substantially adjacent to a breath sampling inlet.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a Continuation of U.S. application Ser. No.14/677,967, filed Jul. 27, 2014 (published as 2015/0208953), which is aContinuation of U.S. application Ser. No. 14/191,394, filed Feb. 26,2014 (published as US 2014/0180157), which is a Continuation of U.S.application Ser. No. 11/914,135, filed Nov. 11, 2007 (published as US2009/0088656), which is the U.S. National Stage of InternationalApplication No. PCT/IL2006/000554, filed May 10, 2006, which claims thebenefit of U.S. Provisional Application No. 60/679,890, filed May 10,2005, the contents of each of which are hereby incorporated by referencein their entireties.

FIELD OF THE DISCLOSURE

The present disclosure generally relates to fluid drying tube(s),particularity for use in the field of breath sampling and analysis.

BACKGROUND

Breath gas analysis is commonly performed to provide information relatedto a patient's condition. An example of a gas analysis often performedis capnography using an analyzer called a capnograph. Capnography is themonitoring of the time dependent respiratory carbon dioxide (CO₂)concentration, which may be used to directly monitor the inhaled andexhaled concentration of CO₂, and indirectly monitor the CO₂concentration in a patient's blood. Capnography may provide informationabout CO₂ production, pulmonary (lung) perfusion, alveolar ventilation(alveoli are hollow cavities in the lungs in which gas exchange is beingperformed) and respiratory patterns. Capnography may also provideinformation related to a patient's condition during anaesthesia, forexample by monitoring the elimination of CO₂ from anaesthesia breathingcircuit and ventilator.

In breath analysis systems, for example capnography, breath gas can besampled either by a mainstream or a sidestream analyzer. In mainstreamanalyzers the sample chamber is positioned within the patient's gasstream near the patient's end of the breathing system. This arrangementis normally heavier and more cumbersome.

In sidestream analysers gas is drawn from the breathing system by atube. The tube, which may be connected to an adaptor near the patient'send of the breathing system, delivers the gas to a sampling place (suchas a sampling chamber). There are several elements that are generallycommon to sidestream breath analysis systems (such as capnographs)including, a monitor that continuously samples and monitors the CO₂ in apatients breath, airway tube(s) and sampling line(s) which may beflexible tube(s) having narrower diameter(s) than the airway tube(s),and are adapted used to connect between the patient airway tube(s) andthe distant analyzer, such as the capnograph monitor. Along this tube,the patient's breath is continuously sampled.

It is usually preferable that the sampling line is clear of liquids inthe fluid sample at all times, in order to permit continuous,non-interfered monitoring. Such liquids are common in patient samplingsystems, and have several origins, for example:

-   -   condensed out liquids from the highly humidified air provided to        and exhaled from the patient. These liquids typically accumulate        both in the patient airway and in the sampling line tubing;    -   secretions from the patient, typically found in the patient        airway; and    -   medications or saline solution provided to the patient during        Lavage, suction and nebulization procedures.

Condensed out liquids generally refer to water that condenses out fromthe humidity (the water vapor in a air or in other gas) in the samplingtubes. Condensed out liquids is a major problem commonly hinderingbreath analyses, particularly sidestream capnography. The internalhumidity levels in the tubes are high especially in proximity to thebreath collection area since the exhaled and inhaled breath is humid andrelatively warm. This is also the case in intubated patients who aregenerally artificially ventilated with gas (for example, air) having upto 100% humidity at a temperature normally above ambient temperature(for example, about 34° C.), depending on the airway humidificationsystem and patient needs. The humidity (water vapors) often condenses onthe tube particularly as the tube is extended farther from the breathcollection area due to the temperature decreases.

Several methods have been developed in order to keep the sampling linefree of liquids such as those mentioned above, particularly moisture.Some methods are designed to prevent liquids from entering the samplingline (for example, as described in U.S. Pat. No. 5,857,461) and some aredesigned to remove such liquids if they entered the sampling line orwere created in it.

In addition to the aforementioned preventive steps, it is commonpractice in side-stream capnography to use tubes that are made of orinclude drying materials. The internal humidity levels in the tubes,especially in proximity to the breath collection area, are high, andsince airway temperature, dictated by the airway humidification systemand patient needs, is relatively high, there is a clear need for amaterial which will bring down the internal humidity of the sampledbreath before the humid gas would condense out when flowing towards thegas analyzer (for example capnograph), cooled by the ambient air. Onesuch suitable material is Nafion®.

Nafion® is a copolymer of tetrafluoroethylene (Teflon®) andperfluoro-3,6-dioxa-4-methyl-7-octene-sulfonic acid. Like Teflon,Nafion® is highly resistant to chemical attack, but the presence of itsexposed sulfonic acid groups confers unusual properties. Sulfonic acidhas a very high water-of-hydration, absorbing 13 molecules of water forevery sulfonic acid group in the polymer; consequently, Nafion® absorbs22% by weight of water. Since the Nafion® specifically reacts withwater, gases being dried or processed are usually entirely unaffected.Nafion® tubing, which comprises an ion exchanger, has the ability toequate internal humidity levels with the external ambient humidity.

The efficiency of drying materials such as Nafion® in dehumidifying agas sample is dependant mainly on the following parameters:

-   -   the rate of flow of gas passing through the drying tube (a tube        that include a drying material such as Nafion®), wherein the        slower the flow rate, the more efficient is the dehumidifying        process;    -   the tube diameter, wherein the smaller the diameter, the more        efficient is the dehumidifying process;    -   the wall thickness, wherein the thinner the wall, the more        efficient is the dehumidifying process;    -   the humidity gradient inside and outside of the tube, wherein        the greater the difference in humidity inside and outside, the        more efficient is the dehumidifying process;    -   the temperature of the humid gas, wherein the higher the        temperature, the more efficient is the dehumidifying process;        and    -   The movement of air around the drying tube (such as Nafion®        tube); wherein the faster the movement, the more efficient is        the dehumidifying process.

Materials like Nafion® tend to be expensive and their cost is dependanton the length of material required. Since gas sampling lines (forexample in a capnograph) are disposable in nature, one must design thesample line including the Nafion® tube in the most effective way so asto use the least amount of drying material such as Nafion® necessary forthe purpose required. Hence one must use the above listed parameters inorder to provide the optimal solution.

Further, the patient airway tubes are typically furnished with largediameters, to address large flows of gas, typically up to about 30liters per minute. Such patient airway tubes may use heating systems tokeep the humidified air from condensing out. On the other hand, gassampling lines (for example in a capnograph) often use small (internaland external) diameter bore tubings to enable the undisturbed flow ofthe sampled breath at low flow rates, such as about 50 ml/min. Thesubstantial change in diameters between the patient airway tubes and thesampling tubes may create rapid drop in temperatures when passing fromthe patient airway, through the sampling port to the sample line. Thistemperature drop results in rapid condensation of the humidified breathbefore reaching the drying tube (which may include for example,Nafion®), and hence before the internal humidity can be equated with thelower ambient humidity. Since the temperature generally dropssignificantly before the gas reaches the drying material (while asaforementioned, drying materials such as Nafion® operate moreefficiently at higher temperatures) and since water may have alreadycondensed out in the sampling line before the gas reaches the dryingmaterial (while drying materials such as Nafion® are more efficient inremoving humidity than water), drying material such as Nafion® are oftenused in an ineffective manner. Prior art refers to the problem ofmoisture in gas sampling tubes. U.S. Pat. No. 6,783,573, for example,refers to the “moisture problem” and teaches away from placing a dryermechanism in the connector adjacent to, or proximate to, the respiratoryoutput device (e.g., the mask, cannula, or etc.). U.S. Pat. No.6,783,573 specifically states that this approach has drawbacks.Moreover, U.S. Pat. No. 6,783,573 states “the dryer mechanism disposedproximate the patient is ineffective, . . . ” (column 1, lines 64-65).U.S. Pat. No. 6,783,573.

There is thus a need for sampling systems that are adapted to reduce theamount of liquids, particularly moisture, that form along the samplingtubes.

SUMMARY

The following embodiments and aspects thereof are described andillustrated in conjunction with systems, tools and methods, which aremeant to be exemplary and illustrative, not limiting in scope. Invarious embodiments, one or more of the above-described problems havebeen reduced or eliminated, while other embodiments are directed toother advantages or improvements.

In accordance with some embodiments, there is provided an exhaled breathmoisture reduction system including a dryer mechanism and a connectoradapted to connect the dryer mechanism proximate to a respiratory outputdevice.

The connector may be adapted to connect between a dryer mechanism and arespiratory output device in such way that substantially retains the gassample characteristics (for example, humidity and temperature) until itreaches the dryer mechanism.

In accordance with some embodiments, there is provided an exhaled breathmoisture reduction system including a dryer mechanism adjacent to aconnector adapted to connect the dryer mechanism to a respiratory outputdevice, wherein the dryer mechanism comprises a reinforcing element.

In accordance with additional embodiments, there is provided an exhaledbreath moisture reduction sleeve including a material adapted to reducemoisture and a connector adapted to connect the sleeve substantiallyadjacent to a breath sampling inlet.

In accordance with additional embodiments, there is provided an exhaledbreath sampling assembly including an airway adaptor and a moisturereduction sleeve comprising a material adapted to reduce moisture and aconnector adapted to connect the sleeve substantially adjacent to abreath sampling inlet within the adaptor.

In accordance with some embodiments of the present disclosure, there isprovided an exhaled breath sampling assembly including a cannula, amoisture reduction sleeve including a material adapted to reducemoisture, and a connector adapted to connect the sleeve substantiallyadjacent to a breath sampling inlet within the cannula, wherein thesleeve is adapted to be placed on a subject's face.

In accordance with additional embodiments, there is provided a breathanalyzer including a moisture reduction sleeve comprising a materialadapted to reduce moisture and a connector adapted to connect the sleevesubstantially adjacent to a breath sampling inlet.

In accordance with additional embodiments, there is provided a method ofsampling breath including attaching an exhaled breath moisture reductionsleeve substantially adjacent to a breath sampling inlet.

In accordance with other embodiments, there is provided a method ofsampling breath including attaching an exhaled breath moisture reductionsleeve substantially adjacent to a breath sampling inlet of a cannula,wherein the moisture reduction sleeve is placed on a subject's face.

In addition to the exemplary aspects and embodiments described above,further aspects and embodiments will become apparent by reference to thefigures and by study of the following detailed description.

BRIEF DESCRIPTION OF THE FIGURES

Exemplary embodiments are illustrated in referenced figures. It isintended that the embodiments and figures disclosed herein are to beconsidered illustrative, rather than restrictive. The disclosure,however, both as to organization and method of operation, together withobjects, features, and advantages thereof, may best be understood byreference to the following detailed description when read with theaccompanying figures, in which:

FIG. 1 schematically illustrates an exploded view of a sampling systemconstructed and operative in accordance with some embodiment of thepresent disclosure;

FIG. 2 schematically illustrates an assembled view of the samplingsystem of FIG. 1;

FIG. 3 shows a sectional illustration taken along section lines III-IIIin FIG. 2;

FIG. 4 schematically illustrates an exploded view of a sampling systemconstructed and operative in accordance with other embodiment of thepresent disclosure;

FIG. 5 schematically illustrates an assembled view of the samplingsystem of FIG. 4;

FIG. 6 schematically illustrates a sampling system constructed andoperative in accordance with additional embodiments of the presentdisclosure;

FIG. 7 shows a sectional illustration taken along section lines V-V inFIG. 4; and

FIG. 8 shows a schematic illustration of a sampling system constructedand operative in accordance with some embodiment of the presentdisclosure.

It will be appreciated that for simplicity and clarity of illustration,elements shown in the figures have not necessarily been drawn to scale.For example, the dimensions of some of the elements may be exaggeratedrelative to other elements for clarity. Further, where consideredappropriate, reference numerals may be repeated among the figures toindicate corresponding or analogous elements.

DETAILED DESCRIPTION

While a number of exemplary aspects and embodiments have been discussedabove, those of skill in the art will recognize certain modifications,permutations, additions and sub-combinations thereof. It is thereforeintended that the following appended claims and claims hereafterintroduced be interpreted to include all such modifications,permutations, additions and sub-combinations as are within their truespirit and scope.

As discussed hereinabove there is a need for sampling systems that areadapted to reduce the amount of liquids, particularly moisture, that areformed along and/or within the sampling tubes. It was found thatimplanting a dryer mechanism (such as but not limited to a dryer tubethat may include, for example, Nafion®) within (in such way that thedrying material is not in direct contact with the highly humid ambientenvironment) or otherwise associated with the airway adaptor or as closeto the airway adaptor as possible reduces the amount of liquids,particularly moisture in the sampling system.

The airway adaptor, which may be a part of a respiratory output deviceor may be adapted to fit into a respiratory output device, is adapted toallow the transfer of the warmed air of the patient's airway flow (fromeither natural breathing or artificial ventilation) and is generallydisposed near the patient. Particularly, the airway adaptor may be apart of or fit into a respiratory output device, which is adapted foruse in intubated patients, for example patients being artificiallyventilated. A respiratory output device may be for example, a mask,airway tube, endotracheal tube, intubation tube and the like.

The dryer mechanism may preferably be disposed adjacent to, or proximateto, the airway adaptor and/or the respiratory output device (forexample, a mask, cannula, an airway tube, endotracheal tube, intubationtube and the like) in such a way that the warmed air in the patient'sairway flow (from either natural breathing or artificial ventilation)heats the dryer mechanism (such as but not limited to, a dryer tube thatmay include for example, Nafion®), thus maintaining a higher temperatureof the humid gas, increasing the efficiency of the dryer mechanism andreducing humidity in the sampled gas. Additionally, an isolator, forexample, formed of a foamy material, may be placed around the regionconnecting between the dryer mechanism and the breath sampling inlet, inorder to maintain the temperature of the humid gas when reaching thedryer mechanism.

It is noted that in the drying material of the dryer mechanism (forexample, Nafion® tube) may be preferably placed adjacent to, orproximate to, the airway adaptor and/or the respiratory output device insuch way were it is not in the direct stream of the patients exhaledbreath, since this would create a high ambient humidity environment tothe drying material, and as mentioned hereinabove, the dryer material ismore efficient when the gradient between inside and outside is large.

Provided herein, according to embodiments of the disclosure,configurations in which the warmed air of the patient's airway flow(from either natural breathing or artificial ventilation) heats thedryer mechanism and thus maintain a higher temperature of the humid gas.These configurations increase the efficiency of the dryer mechanism andreduce humidity and/or moisture in the sampled gas as well as to preventany liquids condensing out prior to reaching the dryer mechanism, forexample, dryer tube, (as mentioned herein, condensed out liquidsreaching the, render the dryer mechanism, for example, dryer tube, lessefficient by a cooling effect, in other words, the dryer mechanismshould preferably be used to dehumidify rather than to remove water).The dryer mechanism, for example, may be wound around the airway adaptorto increase its temperature (and the temperature of the gas flowingthrough it) and thus the dryer mechanism's efficiency.

In accordance with some embodiments of the present disclosure,particularly when used with a cannula, for example with non-intubatedpatients that are anyway wearing a cannula that is secured upon thepatients face, the dryer mechanism, for example, Nafion® tube, may beplaced on or near the patient's face, as close as possible to thecannula so as to gain heat from the patient. There is thus provided, inaccordance with some embodiments of the present disclosure, an exhaledbreath sampling assembly including a cannula, a moisture reductionsleeve including a material adapted to reduce moisture, and a connectoradapted to connect the sleeve substantially adjacent to a breathsampling inlet within the cannula, wherein the sleeve is adapted to beplaced on a subject's face.

In accordance with some embodiments, there is provided an exhaled breathmoisture reduction system including a dryer mechanism and a connectoradapted to connect the dryer mechanism proximate to a respiratory outputdevice. The connector may be adapted to connect between a dryermechanism and a respiratory output device in such way that substantiallyretains the gas sample characteristics (for example, humidity andtemperature) until it reaches the dryer mechanism. The connector may bemolded on the dryer mechanism and/or a separate element. The dryermechanism may include a material adapted to absorb moisture. The dryermechanism may include a material adapted to pass moisture.

When used, the respiratory output device is generally maintained at atemperature higher than ambient temperature, because it passes theexhaled breath of a subject. The proximity between the dryer mechanismand the respiratory output device may allow maintaining the dryermechanism at a relatively high temperature and thus increase theefficiency of the moisture (and/or humidity) reduction. The system mayfurther include a gripper adapted to cover or partially cover theconnector. In addition to being a grabbing point, the gripper mayinclude an insulating material. The insulating material may be a thermalinsulator and may be adapted to maintain the relatively high temperatureof the gas passing from the respiratory output device to the dryermechanism.

The term “proximate to” may refer to 3 cm (centimeters) or less, forexample, 1 cm or less, 0.5 cm or less). The closer the dryer mechanismto the respiratory output device, the less heat is lost.

In accordance with some embodiments, there is provided an exhaled breathmoisture reduction system including a dryer mechanism adjacent to aconnector adapted to connect the dryer mechanism to a respiratory outputdevice, wherein the dryer mechanism comprises a reinforcing element.

The connector may be adapted to connect between a dryer mechanism and arespiratory output device in such way that substantially retains the gassample characteristics (for example, humidity and temperature) until itreaches the dryer mechanism.

The dryer mechanism may include a material adapted to absorb moisture.The dryer mechanism may include a material adapted to pass moisture.

The proximity between the dryer mechanism and the connector to therespiratory output device may allow maintaining the dryer mechanism at arelatively high temperature and thus increase the efficiency of themoisture (and/or humidity) reduction.

The term “adjacent to” may refer to 3 cm (centimeters) or less, forexample, 1 cm or less, 0.5 cm or less). “Adjacent to” may also include aconnector that is molded on the dryer mechanism.

In accordance with additional embodiments, there is provided an exhaledbreath moisture reduction sleeve including material(s) adapted to reducemoisture and a connector adapted to connect the sleeve substantiallyadjacent to a breath sampling inlet.

In accordance with additional embodiments, there is provided an exhaledbreath sampling assembly including an airway adaptor and a moisturereduction sleeve comprising a material adapted to reduce moisture and aconnector adapted to connect the sleeve substantially adjacent to abreath sampling inlet within the adaptor.

In accordance with additional embodiments, there is provided a breathanalyzer including a moisture reduction sleeve comprising a materialadapted to reduce moisture and a connector adapted to connect the sleevesubstantially adjacent to a breath sampling inlet.

The connector may be adapted to connect between a dryer mechanism and arespiratory output device in such way that substantially retains the gassample characteristics (for example, humidity and temperature) until itreaches the dryer mechanism.

The dryer mechanism may include a material adapted to absorb moisture.The dryer mechanism may include a material adapted to pass moisture.

In accordance with additional embodiments, there is provided a method ofsampling breath including attaching an exhaled breath moisture reductionsleeve substantially adjacent to a breath sampling inlet (which may bewithin an airway adaptor). Attaching an exhaled breath moisturereduction sleeve substantially adjacent to a breath sampling inlet maybe performed in such way as to substantially retains the gas samplecharacteristics (for example, high temperature) until it reaches thedryer mechanism and thus increase the efficiency of the dryer mechanism.

In accordance with other embodiments, there is provided a method ofsampling breath including attaching an exhaled breath moisture reductionsleeve substantially adjacent to a breath sampling inlet of a cannula,wherein the moisture reduction sleeve is placed on a subject's face.Attaching an exhaled breath moisture reduction sleeve substantiallyadjacent to a breath sampling inlet of a cannula and placing themoisture reduction sleeve on a subject's face may allow substantialretaining of the gas sample characteristics (for example, hightemperature) until it reaches the dryer mechanism and thus increase theefficiency of the dryer mechanism.

A “connector” as referred to herein may include any element that isadapted to bring to objects close to each other. A connector may referto a molded-on connector, which may be a part of the drying mechanismand/or a separate element.

A “dryer mechanism” (or a drying mechanism) as referred to herein mayinclude a dryer tube, a dryer sleeve that include material(s) capable ofabsorbing or passing moisture and/or humidity from a fluid such asexhaled breath. The dryer mechanism may have any other form, for examplea sheet that allows reduction of humidity in sampled exhaled breathwhile maintaining the spacial resolution (and/or special integrity) ofthe collected breath samples. The dryer mechanism may include forexample, Nafion®. The dryer mechanism (such as the dryer tube) mayinclude a reinforcing element.

A “reinforcing element” as referred to herein may include any elementadapted to provide mechanical protection to the dryer mechanism, forexample, prevent fluid flow interruption, damaging, (partially)blocking, bending and/or collapsing of the drying tube. The reinforcingelement may cover essentially or a portion of a dryer mechanism. Thereinforcing element may include, for example, a braiding net or anyother form of mechanical support, such as rigids, rods or the like.

A “respiratory output device” as referred to herein may include, a mask,cannula, airway tube, endotracheal tube, intubation tube and the like.

A “breath sampling inlet” as referred to herein may include an opening,aperture, orifice, valve or the like that is adapted for collection offluid (such as breath exhale) from a subject's airway (such as an airwayadaptor, cannula, airway tube or the like).

A “sleeve” as referred to herein may include a replaceable cylinder or ajacket that may include or be embodied by a drying material. A “sleeve”may also refer to a cylindrically shaped or otherwise tubular piece thatsits over or under a rod, joint, shaft or tube.

A “cannula” as referred to herein may include different types oforal/nasal cannula(s), which may be used to deliver oxygen to patientswho require assistance to breath properly and/or to collect breathsamples from patients to monitor respiration, or to perform bothfunctions. Such cannula(s) may be used when direct ventilation is notprovided. The term “oral/nasal” may refer to the adaptable configurationof such cannula(s) which are designed to be in close proximity to theoral cavity and/or nasal cavity and may also be at least partiallyinserted into the nasal cavity.

Reference is now made to FIG. 1, which schematically illustrates anexploded view of a sampling system constructed and operative inaccordance with some embodiment of the present disclosure and to FIG. 2,which schematically illustrates an assembled view of the sampling systemof FIG. 1. The sampling system 100 is adapted for sampling and analysisof exhaled breath, while reducing the exhaled breath moisture using amoisture reduction system 102 adapted to position a dryer mechanismproximate to a respiratory output device (such as a mask, cannula, oraland/or nasal breath collectors, endotracheal tube intubation tube andthe like). The respiratory output device is generally located near thepatient.

The sampling system 100 includes a moisture reduction system 102, whichincludes a dryer mechanism, particularly a dryer tube 104 and areinforcing element 106. The moisture reduction system 102 furtherincludes a connector 108 that is adapted to connect the dryer tube 104substantially adjacent to a breath sampling inlet 110. The breathsampling inlet 110 is adapted to connect between the connector 108 andthe airway adaptor 120 which may be a part of the respiratory outputdevice (particularly, endotracheal tube, intubation tube and the like).The breath sampling inlet 110 may be integrally formed with the airwayadaptor 120 (as shown) or may be attached to the airway adaptor 120. Theairway adaptor 120 is adapted to connect to a patient respiratory gasoutput mechanism such as an endotracheal tube or intubating tube. Thebreath sampling inlet 110 is shown (partially) within an airway adaptor120. The breath sampling inlet 110 further includes a sampler 112 havingsampling prongs 114, 116 and 118 which are adapted to collect exhaled(and also inhaled) breath. Of course, sampler 112 may be structureddifferently, for example in deferent length, position within the airwayadaptor 120, angle, number and position of sampling prongs and the like.The sampler 112 may include openings and/or funnel shaped collectorsinstead of one or more prongs and/or may include, for example one ormore (for example 1, 2, 3 or more) prongs in each one of the samplingsides.

The moisture reduction system 102 further includes a gripper 122, whichis adapted to (at least partially) cover the connector 108 (as shown inFIG. 2) and may allow the attendant (technician, nurse and the like) tohandle the sampling system 100 without touching and possibly damagingthe dryer tube 104.

The moisture reduction system 102 further includes a molded-on connector126 having a male adaptor 124, which is adapted to connect to thesampling tubing (not shown). The molded-on connector 126 also provides amechanical protection to the dryer tube 104 (which is often of a frailnature).

It is noted that other appropriate connectors and/or adaptors, which mayhave different shapes and/or operative mechanisms, may be used. Thesampling tubing may further include another moisture reduction system(not shown), which may be the same or different from moisture reductionsystem 102 and a coupler that allows the connection of the samplingsystem 100 to a gas analyzer such as a capnograph (not shown).

The dryer tube 104 may include any drying mechanism and/or material thatis capable of reducing the moisture level in the sampling system 100 andthe sampling tubes. For example, the dryer tube 104 may include Nafion®as referred to herein. In another example, the dryer tube 104 mayinclude filters such as microporous filters or molecular sieves(material containing tiny pores of a precise and uniform size that maybe used to absorb moisture). The dryer tube 104 may vary in lengthand/or in diameter. It is generally preferable that the dryer tube isadapted to absorb moisture and is essentially impermeable to gases. Afilter of molecular sieve into which certain materials are impregnatedmay be included in the drying tube. The reinforcing element 106 isadapted to provide mechanical protection to the drying tube 104, forexample prevent flow interruption, damaging, (partially) blocking,bending and/or collapsing of the drying tube 104. The reinforcingelement 106 may cover a portion of the drying tube 104. The reinforcingelement 106 may include, for example, a braiding net (as shown inFIG. 1) or any other form of mechanical support, such as rigid bars.

The connector 108 that is adapted to connect the dryer tube 104substantially adjacent to the breath sampling inlet 110 may vary inshape and or size, for example in a way that would allow minimizing thedistance between the dryer tube 104 and the breath sampling inlet 110.

The gripper 122 may include an insulating material. The insulatingmaterial may be a thermal insulator (made for example from a foamymaterial) that allows maintaining relatively high temperature of thesampled breath prior to reaching the dryer tube 104. Maintainingrelatively high temperature of the sampled breath will in turn reducethe condensing out of water and thus increase the efficiency of thedryer tube 104.

Reference is now made to FIG. 3, which shows a sectional illustrationtaken along section lines III-III in FIG. 2. The sampling system 100includes a moisture reduction system 102, which includes a dryer tube104 and a reinforcing element 106. The moisture reduction system 102further includes a connector 108 that is adapted to connect the dryertube 104 substantially adjacent to a breath sampling inlet 110. FIG. 3particularly demonstrates an example of an essentially proximateconnection between the dryer tube 104, which has a reinforcing element106, and the airway adaptor 120 which is adapted to fit into therespiratory output device (particularly, endotracheal tube, intubationtube and the like). This essentially proximate connection is done usingthe connector 108, which has an inner structure that is adapted to fitthe outer structure of the breath sampling inlet 110 integrally formedwith the airway adaptor 120. It is noted that other appropriateconnectors, inlets and/or adaptors, which may have different shapesand/or operative mechanisms, and are adapted to maintain an essentiallyproximate connection between a drying mechanism, such as the dryer tube104, and a respiratory output device (such as mask, cannula, oral and/ornasal breath collectors, an endotracheal tube, intubation tube and thelike) may be used. Also shown is the gripper 122, which partially coversthe connector 108 and may allow grabbing the sampling system 100 withouttouching and possibly damaging the dryer tube 104.

Reference is now made to FIG. 4, which schematically illustrates anexploded view of a sampling system constructed and operative inaccordance with another embodiment of the present disclosure and to FIG.5, which schematically illustrates an assembled view of the samplingsystem of FIG. 4. The sampling system 200 is adapted for sampling andanalysis of exhaled breath, while reducing the exhaled breath moistureusing a moisture reduction system 202 adapted to position a dryermechanism adjacent to a connector 208 wherein the connector 208 isadapted to connect the dryer mechanism to a respiratory output device(such as a mask, cannula, oral and/or nasal breath collectors,endotracheal tube intubation tube and the like).

The sampling system 200 includes a moisture reduction system 202, whichincludes a dryer mechanism, particularly a dryer tube 204 and areinforcing element 206. The dryer tube 204 is adjacent to a connector208 that is adapted to connect the dryer tube 204 substantially adjacentto a breath sampling inlet 210. The breath sampling inlet 210 is adaptedto connect between the connector 208 (which has knurls or ridges (211))and the airway adaptor 220 which is adapted to fit into the respiratoryoutput device (particularly, endotracheal tube, intubation tube and thelike). The breath sampling inlet 210 may be integrally formed with theairway adaptor 220 (as shown) or may be attached to the airway adaptor220. The breath sampling inlet 210 is shown (partially) within an airwayadaptor 220. The breath sampling inlet 210 further includes a sampler212 having sampling prongs 214 and 216 (shown as an open ended box,having a rectangular cross section) which are adapted to collect exhaled(and also inhaled) breath. Of course, sampler 212 may be structureddifferently, for example in deferent length, position within the airwayadaptor 220, angle, number and position of sampling prongs and the like.The sampler 212 may include openings and/or funnel shaped collectorsinstead of one or more prongs and/or may include, for example one ormore (for example 1, 2, 3 or more) prongs in each one of the samplingsides.

The moisture reduction system 202 further includes a gripper 222, whichis adapted to (at least partially) cover the connector 208 (as shown inFIG. 5) and may allow the attendant (technician, nurse and the like) tohandle the sampling system 200 without touching and possibly damagingthe dryer tube 204. The moisture reduction system 202 further includes amolded-on connector 209 which may cover the end of the dryer tube 204(adjacent to the connector 208). The molded-on connector 209 alsoprovides a mechanical protection to the dryer tube 204 (which is oftenof a frail nature).

The moisture reduction system 202 further includes a molded-on connector226 having a male adaptor 224, which is adapted to connect to thesampling tubing (not shown). The molded-on connector 226 may also coverthe end of the dryer tube 204 (the opposite end from the end adjacent tothe connector 208). The molded-on connector 226 also provides amechanical protection to the dryer tube 104 (which is often of a frailnature).

It is noted that other appropriate connectors and/or adaptors, which mayhave different shapes and/or operative mechanisms, may be used. Thesampling tubing may further include another moisture reduction system(not shown), which may be the same or different from moisture reductionsystem 202 and a coupler that allows the connection of the samplingsystem 200 to a gas analyzer such as a capnograph (not shown).

The dryer tube 204 may include any drying mechanism and/or material thatis capable of reducing the moisture level in the sampling system 200 andthe sampling tubes. For example, the dryer tube 204 may include Nafion®as referred to herein. In another example, the dryer tube 204 mayinclude filters such as microporous filters or molecular sieves(material containing tiny pores of a precise and uniform size that maybe used to absorb moisture). The dryer tube 204 may vary in lengthand/or in diameter.

The reinforcing element 206 is adapted to provide mechanical protectionto the drying tube 204, for example prevent flow interruption, damaging,(partially) blocking, bending and/or collapsing of the drying tube 204.The reinforcing element 206 may cover a portion of the drying tube 204.The reinforcing element 206 may include, for example, rigid bars (207)with spaces (207 a) therebetween (as shown in FIG. 4) or any other formof mechanical support, such as a rigid braided net (similar to thatshown in FIG. 1 at 106). The connector 208 that is adapted to connectthe dryer tube 204 substantially adjacent to the breath sampling inlet210 may vary in shape and or size, for example in a way that would allowminimizing the distance between the dryer tube 104 and the breathsampling inlet 210.

The gripper 222 may also include an insulating material. The insulatingmaterial may be a thermal insulator (made for example from a foamymaterial) that allows maintaining relatively high temperature of thesampled breath prior to reaching the dryer tube 204. Maintainingrelatively high temperature of the sampled breath will in turn reducethe condensing out of water and thus increase the efficiency of thedryer tube 204.

Reference is now made to FIG. 6, which schematically illustrates a viewof a sampling system constructed and operative in accordance with anadditional embodiment of the present disclosure.

The sampling system 300 is adapted for sampling and analysis of exhaledbreath, while reducing the exhaled breath moisture using a moisturereduction system 302 adapted to position a dryer mechanism proximate toa respiratory output device (such as a mask, cannula, oral and/or nasalbreath collectors, endotracheal tube intubation tube and the like). Therespiratory output device is generally located on or near the patient.

The sampling system 300 includes a moisture reduction system 302, whichincludes a dryer mechanism, particularly a dryer tube 304 and areinforcing element 306.

The moisture reduction system 302 further includes a molded-on connector309 which may cover the end of the dryer tube 304 and also provide amechanical protection to the dryer tube 304 (which is often of a frailnature). The system 300 further includes a breath sampling inlet 310.The breath sampling inlet 310 is adapted to connect the moisturereduction system 302 (by the molded-on connector 309) substantiallyadjacent to the airway adaptor 320 which is adapted to fit into therespiratory output device (particularly, endotracheal tube, intubationtube and the like). FIG. 6 demonstrates a configuration in which thedryer mechanism (particularly, the moisture reduction system 302 isconnected directly to the airway adaptor 320.

The breath sampling inlet 310 is integrally formed with the airwayadaptor 320. The breath sampling inlet 310 may also be attached to theairway adaptor 320. The breath sampling inlet 310 is shown (partially)within an airway adaptor 320. The breath sampling inlet 310 furtherincludes a sampler 312 having sampling prongs 314, 316 and 318 which areadapted to collect exhaled (and also inhaled) breath. Of course, sampler312 may be structured differently, for example in deferent length,position within the airway adaptor 320, angle, number and position ofsampling prongs and the like. The sampler 312 may include openingsand/or funnel shaped collectors instead of one or more prongs and/or mayinclude, for example one or more (for example 1, 2, 3 or more)prongs/openings in each one of the sampling sides.

The moisture reduction system 302 further includes a gripper (notshown), which is adapted to (at least partially) cover the breathsampling inlet 310 and may allow the attendant (technician, nurse andthe like) to handle the sampling system 300 without touching andpossibly damaging the dryer tube 304. The gripper may include aninsulating material. The insulating material may be a thermal insulator(made for example from a foamy material) that allows maintainingrelatively high temperature of the sampled breath prior to reaching thedryer tube 304.

The moisture reduction system 302 further includes a molded-on connector326 having a male adaptor 324, which is adapted to connect to thesampling tubing (not shown). The molded-on connector 326 also provides amechanical protection to the dryer tube 304 (which is often of a frailnature).

It is noted that other appropriate connectors and/or adaptors, which mayhave different shapes and/or operative mechanisms, may be used. Thesampling tubing may further include another moisture reduction system(not shown), for example, a filter of molecular sieve into which certainmaterials are impregnated such as to form drying system which is adaptedto absorb moisture and is essentially impermeable to gases. The moisturereduction system may be the same or different from moisture reductionsystem 102 and a coupler that allows the connection of the samplingsystem 100 to a gas analyzer such as a capnograph (not shown).

The dryer tube 304 may include any drying mechanism and/or material thatis capable of reducing the moisture level in the sampling system 300 andthe sampling tubes. For example, the dryer tube 304 may include Nafion®as referred to herein. In another example, the dryer tube 304 mayinclude filters such as microporous filters or molecular sieves(material containing tiny pores of a precise and uniform size that maybe used to absorb moisture). The dryer tube 304 may vary in lengthand/or in diameter.

The reinforcing element 306 is adapted to provide mechanical protectionto the drying tube 304, for example prevent flow interruption, damaging,(partially) blocking, bending and/or collapsing of the drying tube 304.The reinforcing element 306 may cover a portion of the drying tube 304.The reinforcing element 306 may include, for example, a braiding net orany other form of mechanical support, such as rigid bars.

Reference is now made to FIG. 7, which shows a sectional illustrationtaken along section lines V-V in FIG. 6. The sampling system 300includes a moisture reduction system 302, which includes a dryer tube304 and a reinforcing element 306. The moisture reduction system 302further includes a molded-on connector 309 which may cover the end ofthe dryer tube 304 and a breath sampling inlet 310. The breath samplinginlet 310 is adapted to connect the dryer tube 304 (with or without themolded-on connector 309) substantially adjacent to the airway adaptor320 which is adapted to fit into the respiratory output device(particularly, endotracheal tube, intubation tube and the like). FIG. 3particularly demonstrates an example of an essentially proximateconnection between the dryer tube 304, which has a reinforcing element306, and the airway adaptor 320 which is a part of the respiratoryoutput device (particularly, endotracheal tube, intubation tube and thelike). It is noted that other appropriate, inlets (which may also havethe functionality of connectors) and/or adaptors, having differentshapes and/or operative mechanisms, and are adapted to maintain anessentially proximate connection between a drying mechanism, such as thedryer tube 304, and a respiratory output device (such as mask, cannula,oral and/or nasal breath collectors, an endotracheal tube, intubationtube and the like) may be used.

Reference is now made to FIG. 8, which shows a schematic illustration ofa sampling system constructed and operative in accordance with someembodiment of the present disclosure. The sampling system 400 is adaptedfor sampling and analysis of exhaled breath, while reducing the exhaledbreath moisture using a moisture reduction system 402 (shown as a dryertube) adapted to position a dryer mechanism proximate to a respiratoryoutput device (such as a mask, cannula, oral and/or nasal breathcollectors, endotracheal tube intubation tube and the like). Therespiratory output device is generally located near the patient.

The sampling system 400 includes a moisture reduction system 402, whichincludes a dryer mechanism. The moisture reduction system 402 furtherincludes a molded-on connector 409 which may cover the end of the dryertube and also provide a mechanical protection to the dryer tube (whichis often of a frail nature). The system 400 further includes a breathsampling inlet 410. The breath sampling inlet 410 is adapted to connectthe moisture reduction system 402 (by the molded-on connector 409)substantially adjacent to the airway adaptor 420 which is adapted to fitinto the respiratory output device (particularly, endotracheal tube,intubation tube and the like). FIG. 8 demonstrates a configuration inwhich the dryer mechanism (particularly, the moisture reduction system402 is connected directly to the airway adaptor 420, similar to themoisture reduction system 302 shows in FIG. 6, however the moisturereduction system 402 is wound around the airway adaptor 420). Thisconfiguration is adapted to increase the efficiency of the dryermechanism and reduce humidity and/or moisture in the sampled gas as bywinding the moisture reduction system 402 around the airway adaptor 420,the warmed air of the patient's airway flow (from either naturalbreathing or artificial ventilation) heats the dryer mechanism and thusmaintain a higher temperature of the humid gas.

The breath sampling inlet 410 is integrally formed with the airwayadaptor 420. The breath sampling inlet 410 may also be attached to theairway adaptor 420. The breath sampling inlet 410 is shown (partially)within an airway adaptor 420. The breath sampling inlet 410 furtherincludes a sampler 412 having sampling prong(s) 414 (only one shown, butthere may be more) which is (are) adapted to collect exhaled breath. Ofcourse, sampler 412 may be structured differently, for example indeferent length, position within the airway adaptor 420, angle, numberand position of sampling prongs and the like. The sampler 412 mayinclude openings and/or funnel shaped collectors instead of one or moreprongs and/or may include, for example one or more (for example 1, 2, 3or more) prongs/openings in each one of the sampling sides.

The moisture reduction system 402 further includes a gripper 422, whichis adapted to (at least partially) cover the breath sampling inlet 410and may allow the attendant (technician, nurse and the like) to handlethe sampling system 400 without touching and possibly damaging the dryertube. The gripper may include an insulating material. The insulatingmaterial may be a thermal insulator (made for example from a foamymaterial) that allows maintaining relatively high temperature of thesampled breath prior to reaching the dryer tube.

The moisture reduction system 402 further includes a molded-on connector426 having a male adaptor 424, which is adapted to connect to thesampling tubing (not shown). The molded-on connector 426 also provides amechanical protection to the dryer tube (which is often of a frailnature).

While certain features of the disclosure have been illustrated anddescribed herein, many modifications, substitutions, changes, andequivalents will now occur to those skilled in the art. It is,therefore, to be understood that the appended claims are intended tocover all such modifications and changes as fall within the true spiritof the disclosure.

What is claimed is:
 1. A system comprising: a moisture reduction systemcomprising a dryer tube, wherein the dryer tube comprises an inlet, anoutlet, and a material extending between the inlet and the outlet andconfigured to absorb moisture, and wherein the material is essentiallyimpermeable to gases; a respiratory device comprising an adaptor havinga first central bore; a breath sampling inlet extending from the adaptorand configured to collect a breath sample of a patient, wherein thebreath sampling inlet comprises a proximal end, a distal end, and asecond central bore extending between the proximal end and the distalend; a first connector at least partially covering an outer surface ofthe inlet of the dryer tube and configured to couple the dryer tube tothe breath sampling inlet; and a second connector comprising a couplerconfigured to connect the moisture reduction system to a capnograph, andfurther comprising a reinforcing element disposed along at least aportion of a length of the dryer tube, wherein the dryer tube extendsthrough the first connector and wherein the reinforcing element extendspartially through the first connector.
 2. The system of claim 1, whereinthe breath sampling inlet is integrally formed with the adaptor.
 3. Thesystem of claim 1, wherein at least a portion of the distal end of thebreath sampling inlet covers at least a portion of the first connector.4. The system of claim 1, wherein the first connector is molded onto theinlet of the dryer tube.
 5. The system of claim 1, wherein the distalend of the breath sampling inlet is tapered.
 6. The system of claim 1,wherein the second central bore of the breath sampling inlet comprises afirst diameter and a second diameter that is less than the firstdiameter such that a step is formed at a transition between the firstdiameter and the second diameter.
 7. The system of claim 6, wherein anend of the first connector of the dryer tube abuts the step when thedryer tube is coupled to the breath sampling inlet via the firstconnector.
 8. The system of claim 1, comprising a sampler disposedwithin the first central bore and forming part of the proximal end ofthe breath sampling inlet, wherein the sampler comprises one or moreopenings fluidly coupled to the second central bore and configured tocollect the breath sample of the patient.
 9. The system of claim 1,wherein a portion of the breath sampling inlet is within the firstcentral bore of the adaptor.
 10. The system of claim 1, wherein thedryer tube extends radially away from the adaptor.
 11. The system ofclaim 1, wherein the dyer tube is coiled around the adaptor.
 12. Thesystem of claim 1, wherein the dryer tube material is a copolymer oftetrafluoroethylene and perfluoro-3,6-dioxa-4-methyl-7-octene sulfonicacid.
 13. The system of claim 1, wherein the respiratory devicecomprises an endotracheal tube or an intubation tube.
 14. A moisturereduction device comprising: a dryer tube having an inlet, an outlet,and a material extending between the inlet and the outlet, wherein thematerial is configured to absorb moisture, and wherein the material isessentially impermeable to gases; a first connector coupled to the inletof the dryer tube and comprising a first end and a second end; a secondconnector comprising a coupler configured to connect the moisturereduction device to a capnograph; and a breath sampling inlet extendingfrom an adaptor of a respiratory device and configured to collect asample breath of a patient, wherein the breath sampling inlet comprisesa proximal end, a distal end, and a central bore extending between theproximal end and the distal end, and the first connector couples thedryer tube to the breath sampling inlet, further comprising areinforcing element disposed along at least a portion of a length of thedryer tube, wherein the dryer tube extends through the first connectorand wherein the reinforcing element extends partially through the firstconnector.
 15. The moisture reduction system of claim 14, wherein thecentral bore comprises a first diameter and a second diameter that issmaller than the first diameter thereby forming a step at a transitionbetween the first diameter and the second diameter, and wherein thefirst end of the first connector abuts the step when the dryer tube iscoupled to the breath sampling inlet via the first connector.
 16. Amoisture reduction device comprising: a dryer tube having an inlet, anoutlet, and a material extending between the inlet and the outlet,wherein the material is configured to absorb moisture, and wherein thematerial is essentially impermeable to gases; a first connector at leastpartially covering an outer surface of the inlet of the dryer tube; asecond connector comprising a coupler configured to connect the moisturereduction device to a capnograph; and a breath sampling inlet extendingfrom an adaptor of a respiratory device and configured to collect abreath sample of a patient, wherein the breath sampling inlet comprisesa proximal end, a distal end, and a central bore extending between theproximal end and the distal end and the first connector is configured toconnect the dryer tube to the breath sampling inlet, wherein the distalend of the breath sampling inlet is tapered, further comprising areinforcing element disposed along at least a portion of a length of thedryer tube, wherein the dryer tube extends through the first connectorand wherein the reinforcing element extends partially through the firstconnector.
 17. The moisture reduction device of claim 16, wherein thecentral bore comprises a first diameter and a second diameter that issmaller than the first diameter thereby forming a step at a transitionbetween the first diameter and the second diameter, and wherein a firstend of the first connector abuts the step when the dryer tube is coupledto the breath sampling inlet.